Enoxaparin and fibrinolysis: ExTRACTing prognosis from bleeding complications.
نویسندگان
چکیده
This editorial refers to ‘One-year outcomes after a strategy using enoxaparin vs. unfractionated heparin in patients undergoing fibrinolysis for ST-segment elevation myocardial infarction: 1-year results of the ExTRACTTIMI 25 trial’, by D.A. Morrow et al., on page 2097 and ‘Relations between bleeding and outcomes in patients with ST-elevation myocardial infarction in the ExTRACT-TIMI 25 trial’, by R.P. Giugliano et al., on page 2103
منابع مشابه
Outcomes and optimal antithrombotic therapy in women undergoing fibrinolysis for ST-elevation myocardial infarction.
BACKGROUND The manifestations, complications, and outcomes of cardiovascular disease differ between women and men. The safety and efficacy of pharmacological reperfusion therapy in women with ST-elevation myocardial infarction are of particular interest. METHODS AND RESULTS We investigated outcomes in the Enoxaparin and Thrombolysis Reperfusion for Acute Myocardial Infarction Treatment-Thromb...
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BACKGROUND This study aimed to assess whether the efficacy of tranexamic acid (TXA) would be altered when rivaroxaban or enoxaparin was used for thromboprophylaxis in primary total knee replacement (TKR). It was hypothesized that the hemostatic effect of TXA would be better with the use of enoxaparin. MATERIAL AND METHODS A randomized clinical trial was conducted on 194 patients undergoing prim...
متن کاملEnoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction.
BACKGROUND Unfractionated heparin is often used as adjunctive therapy with fibrinolysis in patients with ST-elevation myocardial infarction. We compared a low-molecular-weight heparin, enoxaparin, with unfractionated heparin for this purpose. METHODS We randomly assigned 20,506 patients with ST-elevation myocardial infarction who were scheduled to undergo fibrinolysis to receive enoxaparin th...
متن کاملEnoxaparin for 7 days was better than unfractionated heparin for 2 days for reducing death and MI but not bleeding in STEMI.
M e t h o d s Design: Randomized controlled trial (The Enoxaparin and Thrombolysis Reperfusion for Acute MI Treatment−Thrombolysis in MI [ExTRACT-TIMI] 25 study). Allocation: Concealed.* Blinding: Blinded (clinicians, patients, {data collectors, outcome assessors, and manuscript writers}†.* Follow-up period: 30 days. Setting: 674 centers in 48 countries. Patients: 20 506 patients ≥ 18 years of ...
متن کاملMeta-analysis of randomized trials comparing enoxaparin versus unfractionated heparin as adjunctive therapy to fibrinolysis in ST-elevation acute myocardial infarction.
CRD summary This review assessed the effect of using enoxaparin, a low molecular weight heparin, as an additional therapy with fibrinolytic treatment (such as streptokinase) in people with ST-segment elevation acute myocardial infarction. The authors concluded that enoxaparin was more effective than unfractionated heparin. However, the rates of major bleeding when using enoxaparin were signific...
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عنوان ژورنال:
- European heart journal
دوره 31 17 شماره
صفحات -
تاریخ انتشار 2010